swelling between knuckles

I have swelling between the index knuckle and the middle knuckle as well as between the thumb and index knuckle. It becomes painful in the area and the knuckles for days before it swells and stays that way though slightly less until the swelling goes away. I've had a battery of blood tests for arthritis but all were negative. The swelling occured once before and then reduced. The knuckle discomfort in both hands has been occuring for several years now though the swelling is very recent and only in one hand - not my dominant hand. What could be causing this?
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